Angelica Charlotte Pickles is the main antagonist of the series. While this is so, she acts more as an antihero in the films and often sides with the babies at the end, against the films' respective main villains. She is voiced by Cheryl Chase in Rugrats and All Grown Up!, and is among the series' original characters. She is a spoiled brat and the adorable and very beautiful cousin of Tommy and Dil Pickles. In 2002, TV Guide declared Angelica Pickles 7th in their list of "Top 50 Greatest Cartoon Characters of All Time". She is the arch-enemy of Tommy Pickles and the other Rugrats. Her middle name is 'Charlotte', meaning she is named after her mother, Charlotte. She claims to be 'the prettiest, most beautiful kid in the universe' (which she is). Angelica carries her favorite doll, Cynthia (parody of Barbie), around with her almost everywhere and fills her room with Cynthia merchandise.
Angelica appeared as a Master Model in both the console and handheld version of Nicktoons: Attack of the Toybots. In the console version she appears as a 4-year old appearance the Rugrats show while in the handheld version she appears in her 12-year old appearance from All Grown Up!.