|First Appearance||"The Nightmare Begins" March 30, 2001|
Ms. Bitters is the teacher of Zim's and Dib's class at Skool. A tall, slender old woman of unknown origin or age, she is devoid of any positive emotion, and full of demonic hatred for children. Ms. Bitters was voiced by the late Lucille Bliss. Her first name, if she even has one, is unknown.
Nicktoons: Globs of DoomEdit
Ms. Bitters appears as a non-playable character in Nicktoons: Globs of Doom. She is one of the people who you must save from the goo. She is found on the playground of the school and asks if you can manage to save her, it would be worth an A.